Hemodiafiltration efficacy in treatment of methanol and ethylene glycol poisoning in a 2-year-old girl.

نویسندگان

  • Agnieszka Szmigielska
  • Hanna Szymanik-Grzelak
  • Elżbieta Kuźma-Mroczkowska
  • Maria Roszkowska-Blaim
چکیده

INTRODUCTION Every year about 2.4 million people in USA are exposed to toxic substances. Many of them are children below 6 years of age. Majority of poisonings in children are incidental and related to household products including for example drugs, cleaning products or antifreeze products. Antifreeze solutions contain ethylene glycol and methanol. Treatment of these toxic substances involves ethanol administration, fomepizole, hemodialysis and correction of metabolic acidosis. PURPOSE The aim of the study was to check the efficacy of continuous venovenous hemodiagiltration in intoxication with ethylene glycol and methanol. MATERIAL AND METHODS One year and 7 months old girl after intoxication with ethylene glycol and methanol was treated with continuous venovenous hemodiafiltration instead of hemodialysis because of technical problems (circulatory instability). RESULTS Intravenous ethanol infusion with hemodialtration resulted in rapid elimination of methanol from the body and significantly reduced blood ethylene glycol level. CONCLUSIONS Continuous venovenous hemodiafiltration can be helpful in treatment of ethylene glycol and methanol intoxication.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Translational Antidote Research: A Bedside to Bench Tale

Although antidote development should proceed in an orderly fashion from observation, to experimental and safety studies, to clinical trials, this sequence is not always precisely followed. The development of fomepizole as an antidote for toxic alcohol and glycol poisoning is an example of how this may not be the case. Interest in the development of fomepizole was spurred in the 1960s. Shortly t...

متن کامل

A 13-Year Retrospective Study on Toxic Alcohol Poisoning in Middle Urals, Russia

Background: Toxic alcohol poisonings are responsible for high mortality and morbidity in Russia. This study was aimed to evaluate the trends of harmful ethanol (EtOH) drinking as well as methanol (MeOH), isopropanol (IPA) and ethylene glycol (EG) poisonings in the Middle Urals region of Russia. Methods: In this retrospective study, the medical records of patients poisoned with MeOH, IPA and EG ...

متن کامل

Fomepizole for the treatment of pediatric ethylene and diethylene glycol, butoxyethanol, and methanol poisonings.

INTRODUCTION The use and clinical efficacy of the alcohol dehydrogenase inhibitor fomepizole is well established for the treatment of ethylene glycol and methanol poisonings in adults. METHODS A computerized search of the U.S. National Academy of medicine and EMBase databases was undertaken to identify published cases of patients treated with fomepizole. This search strategy identified 14 pub...

متن کامل

Acute Kidney Injury, Myocardial Infarction and Death Following Brake Fluid Poisoning; A Case Report

Background: Ethylene glycol is a toxic alcohol which is used in brake fluid, antifreeze, coolants, preservatives and chemical solvents. Ethylene glycol poisoning usually results in depression of the central nervous system, renal insufficiency and cardiopulmonary compromise, while laboratory findings include metabolic acidosis, increased anion gap, increased osmolar gap and calcium oxalate cryst...

متن کامل

Effectiveness of IV Ethanol Therapy Combined with Hemodialysis in the Treatment of Methanol and Ethylene Glycol Poisoning

Background: The management of methanol and ethylene glycol poisoning includes inhibition of alcohol dehydrogenase by IV ethanol therapy or fomepizole. There is a lack of contemporary information on IV administration of ethanol in this setting. Objective: To evaluate the effectiveness of IV ethanol therapy in combination with hemodialysis for the treatment of methanol and ethylene glycol poisoni...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Developmental period medicine

دوره 19 2  شماره 

صفحات  -

تاریخ انتشار 2015